Effect of Breast Feeding Versus Formula Milk Feeding on the Preterm Infants in the Neonatal Intensive Care Unit at Tobruk Medical Center

Khadeejah Miftah Ali Al-Khurum,; Nasren  Gamal Saleh Al-Fraik,; Eman Issa Berrish Mohamed

doi:10.64516/d9zcm637

Authors

Khadeejah Miftah Ali Al-Khurum, Pediatric Department, Faculty of Medicine, Tobruk University, Tobruk, Libya Author
Nasren Gamal Saleh Al-Fraik, Pediatric Department, Faculty of Medicine, Tobruk University, Tobruk, Libya. Author
Eman Issa Berrish Mohamed Pediatric Department, Faculty of Medicine, Tobruk University, Tobruk, Libya Author

DOI:

https://doi.org/10.64516/d9zcm637

Keywords:

Breast Feeding;, Premature;, Formula Milk.

Abstract

The effect of breast feeding versus formula milk feeding on growth and short-term outcomes among preterm infants in Neonatal Intensive Care Unit at Tobruck Medical Center. This is a case control study over 12 months period was conducted on 52 premature babies admitted in the nursery of Tobruck Medical Center from 1stJan. 2019 till 1stJan. 2020. All admitted preterm babies in the study period were enrolled( n=52) and divided according to feeding pattern into three groups ( babies on exclusive breast milk(n=10), group on bottle milk (n=18)and third group on bottle and breast milk( mixed) (n=24) .These three feeding patterns were compared in terms of their effects on weight gain, Length of hospital stay (LOS), outcome, incidence rate of feeding intolerance, sepsis and incidence rates of complications. The study included 52 premature newborn ,29 males (55.8%) and 23 females (44.2%) with gestational age (GA) ranging (28-36weeks) and BW ranging (900-3.600 grams) and All newborns were Libyan with maternal age ranging(17-37 yrs.) were the Length of hospital stay LOS ranging (1-55days). The most common reported maternal diseases in this study were Urinary tract infection UTI (15,38%) followed by vaginitis and UTI (7,69%),other diseases (1.92%), but the majority 62% without (1.9%) newborn have distension ,1 (1.9) with gastric residual, 1 (1.9%) have poor sucking .Regarding the complication happen in preterm enrolled in this study 3(5.8%) complicated with anemia , apnea , 2 (3.8%) nosocomial infection, 1 (1.9%) jaundice ,1 (1.9%) mixed complication ,were 34 (65.4%) not have complications. 92% of enrolled preterm discharged, 2% transferred and 6% died. We found no significant correlation between types of feeding and inflammation risk (C reactive protein CRP marker).

References

1. Sartorio BT, Coca KP, Marcacine KO, Abuchaim EDSV, Abrão ACFDV. Breastfeeding assessment instruments and their use in clinical practice.RevGaúchaEnferm.2017;38(1)

2. Ministério da Saúde (BR). Secretaria de Atenção à Saúde.Depart- amento de AtençãoBásica. Saúde da criança: aleitamentomaterno e alimentaçãocomplementar. 2. ed. Brasília (DF): Ministério da Saúde; 2015 [citado 2018 out 18]. Disponívelem:htt://bvsms.saude.gov.br/bvs/

publicacoes/saude_cr ianca _a le itam ento_m aterno_ cab23.

3. World Health Organization. International classification of diseases and related health problems. 10t revision. Geneva: World Health Organization; 1992.

4. Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near- terminfants.

5. Petrou S, Mehta Z, Hockley C, Cook-Mozaffari P, Henderson J, Goldacre M. The impact of preterm birth on hospital inpatient admissions and costs during the first 5 years of life.pediatrics2003;112: 1290-7.

6. Petrou S. The economic consequences of preterm birth during the first 10 years of life. BJOG2005;112 Suppl 1;10-5. PMID:15715587.

7. Lawn JE, Wilczynska-Ketende K, Cousens SN. Estimating the causes of 4 million neonatal deaths in the year 2000. Int J Epidemiol 2006;35:706-18.

8. Quigley M, Embleton ND, McGuire W. Formula versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev. 20197;(7): CD002971.

9. A.I. Eidelman, R.J. Schanler, M. Johnston, S. Landers, L. Noble, K. Szucs, et al. Breastfeeding and the use of human milk. Pediatrics, 129 (2012).

10. Ghasemi M, Dehdari T, Mohagheghi P, Gohari M, Zargrzadeh Z. Mothers’ performance on caring for their premature infants: A pilot study. Iran J Nurs. 2012;25:24–33.

11. Mohagheghi p. Textbook of Neonatal Mechanical Ventilation. Tehran, Iran: Tandis; 2008. p. 243.

12. Anderson JW, Johnstone BM, Remley DT. Breast-feeding and cognitive development: A meta-analysis. Am J ClinNutr. 1999; 70(4):525–35.

13. Hussain Z, Khan N. Assessment of the nutritional status of bottle-fed Infants and the prevalence of infections, allergy and diarrhea among bottle fed infants and its comparison with exclusively breast-fed infants aged 0-6 months. J Pediatr Neonatal Care. 2017; 6(4): 00249.

14. Hsu NY, Wu PC, Bornehag CG, Sundell J, Su HJ. Feeding bottles usage and the prevalence of childhood allergy and asthma. ClinDevImmunol. 2012; 2012:158248.

15. Salih KMA. Prevalence, associated profile of severe malnutrition among Sudanese children in Gafar Children Hospital, Khartoum, Sudan. J Sci. 2017; 7(1):7–11.

16. Leung T.N., Roach V.J., Lau T.K. Incidence of preterm delivery in Hong Kong Chinese. Aust. N. Z. J. Obstet. Gynaecol. 1998;38:138–141.

17. Zhongguo Dang Dai Er Ke Za Zhi. Effect of breastfeeding versus formul a milkfeedingon preterm infants in the neonatal intensive care unit May2017;19(5):572-575.

18. Li YW , Yan CY, Yang L, Han Z L Nutrient .2017 May; 9(5): 520.Published online 2017 May20.

19. Beijing Da XueXueBao Yi Xue Ban. 2016 Feb 18;48(1):143-8.

20. Manea A., Boia M., Iacob D., Dima M., Iacob R.E. Benefits of early enteral nutrition in extremely low birth weight infants. Singapore Med. J. 2016;57:616–618.

21. Assad M ., Elliott M.J ., Abraham J.H. Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet. J. Perinatol. 2016;36:216–220.

22. Manzoni P., Stolfi I., Pedicino R., Vagnarelli F., Mosca F., Pugni L., Bollani L ., Pozzi M ., Gomez K ., Tzialla C., et al. Human milk feeding prevents retinopathy of prematurity (ROP) in preterm VLBW neonates . Early Hum. Dev. 2013;89:S64–S68.

23. O'Connor DL , Jacobs J , Hall R , Adamkin D , Auestad N, Castillo M, et al. Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula. J pediatr Gastroenterol Nutr. 2003;37:437–446.

24. Cristofalo E.A ., Schanler R.J ., Blanco C.L ., Sullivan S., Trawoeger R., Kiechl- Kohlendorfer U., Dudell G.,Rechtman D.J., Lee M.L., Lucas A., et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J.pediatr. 2013;163:1592–1595.

25. Henderson G., Anthony M.Y., McGuire W. Formula milk versus maternal breast milk for feeding preterm or low birth weight infants (review) Cochrane Database Syst. Rev. 2007;4:1–9.

26. Lucas A, Fewtrell MS, Morley R, Singhal A, Abbott RA, Isaacs E, et al. Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants. Pediatrics. 2001;108:703–711.

27. Wheeler RE, Hall RT. Feeding of premature infant formula after hospital discharge of infants weighing less than 1800 grams at birth. J Perinatol. 1996;16((Part 1)):111– 116.

Maayan-Metzger A, Avivi S, Schushan-Eisen I, Kuint J. Human milk versus formula feeding among preterm infants: short-term outcomes. Am J Perinatol. 2012;29:121– 126.

28. Cristofalo EA, Schanler RJ, Blanco CL, Sullivan S, T rawoeger R, Kiech l- Kohlendorfer U, et al. Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr. 2013;163:1592–1595 e1.

29. Carlson S.J., Ziegler E.E. Nutrient intakes and growth of very low birth weight infants. J. Perinatol.1998;18:252–258.

30. Roze JC, Darmaun D, Boquien CY, Flamant C, Picaud JC, Savagner C, et al. The apparent breastfeeding paradox in very preterm infants: relationship between breast feeding, early weight gain and neurodevelopment based on results from two cohorts, EPIPAGE and LIFT.BMJ Open.2012;2:e000834. doi: 10.1136/bmjopen-2012- 000834.

31. Harding JE, Cormack BE, Alexander T, Alsweiler JM, Bloomfield FH. Advances in nutrition of the newborn infant. Lancet. 2017;389:1660–1668. doi: 10.1016/S0140- 6736(17)30552

Spiegler J., Preus M., Gebauer C., Bendiks M., Herting E., Gopel W., On Behalf of the German Neonatal Network Does breastmilk influence the development of bronchopulmonary dysplasia?J. Pediatr.2016;169:76–80.e4.

32. Battersby C, Longford N, Mandalia S, Costeloe K, Modi N. Incidence and enteral feed antecedents of severe neonatal necrotisingenterocolitis across neonatal networks in

33. England, 2012-13: a whole-population surveillance study. Lancet. Gastroenterology &Hepatology 2017;2(1):43-51.

34. Schanler R.J. Mother’s own milk, donor human milk, and preterm formulas in the feeding of extremely premature infants. J. Pediatr. Gastroenterol. Nutr. 2007;45(Suppl.

35. Schanler R.J., Lau C., Hurst N.M., Smith E.O. Randomized trial of donor human milk versus preterm formula as substitutes for mothers’ own milk in the feeding of extremely

premature infants. Pediatrics. 2005;116:400–406.

37. Lok, K., Chau, P. H., Fan, H., Chan, K. M., Chan, B. H., Fung, G., & Tarrant, M. (2017). Increase in Weight in Low Birth Weight and Very Low Birth Weight Infants Fed Fortified Breast Milk versus Formula Milk: A Retrospective Cohort.